Computational study of 3-pyridine carboxaldehyde
نویسندگان
چکیده
منابع مشابه
Inhibition of deoxyribonucleotide synthesis by pyridine carboxaldehyde thiosemicarbazones.
inhibited mammalian ribonucleoside diphosphate reductase in vitro. The inhibition was partially reversed by increasing the concentration of the dithiol substrate, but not of ferrous ion, magnesium ion, nucleotide substrate, or allosteric activator. Increasing the concentration of ferrous ion resulted in greater enzymic inhibition, a finding that is consistent with a model in which either the ac...
متن کاملMetabolic effects of some tumor-inhibitory pyridine carboxaldehyde thiosemicarbazones.
SUMMARY 2-F o rmylpy rid i ne thiosemicarbazone (PT), 3-hydroxy-2-formylpyridine thiosemicarbazone (3-HP), and 5-hydroxy-2-formylpyridine thiosemicarbazone (5-HP) are potent inhibitors of the growth of Sarcoma 180 ascites cells. PT is quite toxic to the tumor-bearing host and does not markedly extend the lifespan of mice bearing Sarcoma 180; however, the therapeutic potential of 3-1-IP and 5-HP...
متن کاملA second monoclinic polymorph of (pyridine-2-carboxaldehyde oximato-κ2 N,N′)(pyridine-2-carboxaldehyde oxime-κ2 N,N′)palladium(II) chloride
The asymmetric unit of the title compound, [Pd(C(6)H(5)N(2)O)(C(6)H(6)N(2)O)]Cl, contains one half of a cationic Pd(II) complex and a Cl(-) anion, with a crystallographic mirror plane parallel to the ac plane passing through the Pd and Cl atoms. In the complex, the Pd(II) ion is four-coordinated in a distorted square-planar environment by four N atoms derived from the two chelating ligands. The...
متن کاملThe Carcinostatic Activity of ^-(A^-Heterocyclic Carboxaldehyde Thiosemicarbazones II. 3-Hydroxypyridine-2-carboxaldehyde Thiosemicarbazone1
3-Hydroxypy rid ine-2-carboxaldehyf le thiosemicarbazone (3-HP) has been shown to be active against leukemia L1210, Ehrlich ascites carcinoma, lym]>homa L5178Y, the Lewis lung carcinoma, and adenocarcinoma 755. 3-HP is active, in some in stances, by gavage and also by delayed treatment. 3-HP is a member of a broad class of a-(.Y)-heterocyclic carboxaldehyde thiosemicarbazones, several of which ...
متن کاملThe carcinostatic activity of alpha-(N)-heterocyclic carboxaldehyde thiosemicarbazones. II. 3-Hydroxypyridine-2-carboxaldehyde thiosemicarbazone.
3-Hydroxypy rid ine-2-carboxaldehyf le thiosemicarbazone (3-HP) has been shown to be active against leukemia L1210, Ehrlich ascites carcinoma, lym]>homa L5178Y, the Lewis lung carcinoma, and adenocarcinoma 755. 3-HP is active, in some in stances, by gavage and also by delayed treatment. 3-HP is a member of a broad class of a-(.Y)-heterocyclic carboxaldehyde thiosemicarbazones, several of which ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Material Science Research India
سال: 2010
ISSN: 0973-3469,2394-0565
DOI: 10.13005/msri/070146